More or less, except that the 2D ones aren't expected to have bones or transform points since it's just a sprite, so most everything like projectiles or hit effects will spawn by default at the character's pivot position unless hand modified in the move.

Additionally, it's advised that you use a sprite sheet to get all your sprites so that the game loads the one image sprite sheet into memory instead of getting hiccups when it's loading in/out individual images.

Look at this tutorial that goes over setting up a 2D character an animations:
https://youtu.be/7WHkkioBSMw